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Increased neural progenitors in vascular dementia

Lookup NU author(s): Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry, Professor Raj Kalaria

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Abstract

Since groundbreaking studies demonstrated the presence of progenitor cells in the adult human brain, there have been intense interests in their potential therapeutic application, but to date only limited data has been obtained in man. An immunohistological study was performed in order to examine neurogenesis in both the subventricular and pen-infarct zones of vascular dementia patients compared to age-matched controls.The results were striking, showing a significant increase of progenitor cells in both the subventricular zone and in pen-infarct area in patients with vascular dementia compared to controls, which was sustained even in patients with infarcts occurring more than three months prior to autopsy. Moreover, the pen-infarct response appeared to be unified with that of the subventricular zone via a stream of cells, with some of them differentiating into immature neurons. We conclude that neurogenesis is stimulated in vascular dementia patients and, specifically, in patients with visible infarcts. Progenitors may migrate from the neurogenic niche to areas of infarction and differentiate into neurons, even three months after cerebrovascular damage, thus implicating the feasibility of enhancing neurogenesis as a novel treatment approach. (C) 2010 Elsevier Inc. All rights reserved.


Publication metadata

Author(s): Ekonomou A, Ballard CG, Pathmanaban ON, Perry RH, Perry EK, Kalaria RN, Minger SL

Publication type: Article

Publication status: Published

Journal: Neurobiology of Aging

Year: 2011

Volume: 32

Issue: 12

Pages: 2152-2161

Print publication date: 05/02/2010

ISSN (print): 0197-4580

ISSN (electronic): 1558-1497

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.neurobiolaging.2010.01.007

DOI: 10.1016/j.neurobiolaging.2010.01.007


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