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Multispectral MRI segmentation of age related white matter changes using a cascade of support vector machines

Lookup NU author(s): Dr Michael FirbankORCiD, Professor John O'Brien, Dr Dag Aarsland

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Abstract

White matter changes (WMC) are the focus of intensive research and have been linked to cognitive impairment and depression in the elderly. Cumbersome manual outlining procedures make research on WMC labor intensive and prone to subjective bias. We present a fast, fully automated method for WMC segmentation using a cascade of reduced support vector machines (SVMs) with active learning. Data of 102 subjects was used in this study. Two MRI sequences (T1-weighted and FLAIR) and masks of manually outlined WMC from each subject were used for the image analysis. The segmentation framework comprises pre-processing, classification (training and core segmentation) and post-processing. After pre-processing, the model was trained on two subjects and tested on the remaining 100 subjects. The effectiveness and robustness of the classification was assessed using the receiver operating curve technique. The cascade of SVMs segmentation framework outputted accurate results with high sensitivity (90%) and specificity (99.5%) values, with the manually outlined WMC as reference. An algorithm for the segmentation of WMC is proposed. This is a completely competitive and fast automatic segmentation framework, capable of using different input sequences, without changes or restrictions of the image analysis algorithm. (C) 2012 Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Damangir S, Manzouri A, Oppedal K, Carlsson S, Firbank MJ, Sonnesyn H, Tysnes OB, O'Brien JT, Beyer MK, Westman E, Aarsland D, Wahlund LO, Spulber G

Publication type: Article

Publication status: Published

Journal: Journal of the Neurological Sciences

Year: 2012

Volume: 322

Issue: 1-2

Pages: 211-216

Print publication date: 15/11/2012

Online publication date: 23/08/2012

Acceptance date: 26/07/2012

ISSN (print): 0022-510X

ISSN (electronic): 1878-5883

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.jns.2012.07.064

DOI: 10.1016/j.jns.2012.07.064


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