Lookup NU author(s): Stephen Allen,
Professor Christopher Dennison
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The human copper metallochaperone (CCS) for Cu, Zn-superoxide dismutase (SOD1) has a similar Zn(II) site as that in SOD1. Dimeric CCS converts to a monomer in the reduced Zn(II)-depleted form that weakens the interaction with SOD1. This form of CCS may be fibril-logenic and disease causing, as is the case for demetallated and reduced monomeric SOD1.
Author(s): Allen S, Dennison C
Publication type: Article
Publication status: Published
Journal: RSC Advances
Print publication date: 08/05/2014
ISSN (electronic): 2046-2069
Publisher: Royal Society of Chemistry
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