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Lactoferrin: Antimicrobial activity and therapeutic potential

Lookup NU author(s): Professor Nicholas Embleton, Dr Janet Berrington, Dr Christopher Stewart

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Abstract

Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed. (c) 2013 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Embleton ND, Berrington JE, McGuire W, Stewart CJ, Cummings SP

Publication type: Article

Publication status: Published

Journal: Seminars in Fetal and Neonatal Medicine

Year: 2013

Volume: 18

Issue: 3

Pages: 143-149

Print publication date: 01/06/2013

Online publication date: 16/03/2013

ISSN (print): 1744-165X

ISSN (electronic): 1878-0946

Publisher: W.B Saunders Co. Ltd.

URL: http://dx.doi.org/10.1016/j.siny.2013.02.001

DOI: 10.1016/j.siny.2013.02.001


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