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Lookup NU author(s): Professor Andrew GenneryORCiD
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The advent of reprogramming technology has greatly advanced the field of stem cell biology and nurtured our hope to create patient specific renewable stem cell sources. While the number of reports of disease specific induced pluripotent stem cells is continuously rising, the field becomes increasingly more aware that induced pluripotent stem cells are not as similar to embryonic stem cells as initially assumed. Our state of the art understanding of human induced pluripotent stem cells, their capacity, their limitations and their promise as it pertains to the study and treatment of primary immunodeficiencies, is the content of this review.
Author(s): Weinacht KG, Brauer PM, Felgentreff K, Devine A, Gennery AR, Giliani S, Al-Here W, Schambach A, Zuniga-Pflucker JC, Notarangelo LD
Publication type: Review
Publication status: Published
Journal: Current Opinion in Immunology
Year: 2012
Volume: 24
Issue: 5
Pages: 617-624
Print publication date: 25/07/2012
ISSN (print): 0952-7915
ISSN (electronic): 1879-0372
Publisher: CURRENT BIOLOGY LTD
URL: http://dx.doi.org/10.1016/j.coi.2012.07.001
DOI: 10.1016/j.coi.2012.07.001