Lookup NU author(s): Professor Stephen McHanwell
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Background. Two theories explain the origin of human laryngeal ventricles: (1) ventricles derive from the fifth pharyngeal pouches; (2) development independent from the pouches.Methods. In all, there were 21 serially sectioned human embryos from stages 15 to 23, and 11 fetuses of 9 to 18 weeks. Computer-aided 3-dimentional reconstructions were made.Results. The cranial part of the laryngeal sulcus and future vestibule expands from the pharyngeal floor between the third and fourth pharyngeal pouches during stages 15 and 16 (33-37 days). The primordia of the ventricles appeared at stage 18 (44 days) as 2 lateral swellings in the caudal end of the future vestibule, limited by the third pharyngeal pouches. Active epithelial expansion and subsequent canalization during late embryonic and early fetal periods finalizes their development.Conclusions. The laryngeal ventricles do not derive from the pharyngeal pouches but the median region of the pharyngeal floor between the third and fourth pharyngeal pouches and arches at the caudal end of the future vestibule. (C) 2012 Wiley Periodicals, Inc. Head Neck 35: 361-369, 2013
Author(s): Viejo F, Pascual-Font A, Rivas L, Hernandez-Morato I, Vazquez T, Rodriguez-Niedenfuhr M, McHanwell S, Sanudo JR
Publication type: Article
Publication status: Published
Journal: Head & Neck
Print publication date: 01/03/2013
Online publication date: 14/03/2012
Acceptance date: 20/12/2011
ISSN (print): 1043-3074
Publisher: John Wiley & Sons, Inc.
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