Lookup NU author(s): Dr Suzannah Harnor,
Dr Tommy Rennison,
Dr Celine Cano,
Professor Roger Griffin,
Professor Herbie Newell,
Professor Bernard Golding
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Reaction of methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-alpha-D-glucopyranuronate with 3'-deoxy-3'-fluorothymidine in the presence of trimethylsilyl trifluoromethanesulfonate gave (2R,3R,4S,5S,6S)2-((( 2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-methoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate, which was hydrolysed to 3'-deoxy-3'-fluorothymidine-5'-glucuronide. Analysis of this reference standard by high performance liquid chromatography enabled the identification of [F-18]3'-deoxy-3'-fluorothymidine-5'-glucuronide in blood samples from six human patients who had been administered [F-18]3'-deoxy-3'-fluorothymidine.
Author(s): Harnor SJ, Rennison T, Galler M, Cano C, Griffin RJ, Newell DR, Golding BT
Publication type: Article
Publication status: Published
Print publication date: 01/01/2014
ISSN (print): 2040-2503
ISSN (electronic): 2040-2511
Publisher: Royal Society of Chemistry
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