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Polymeric membranes for guided bone regeneration

Lookup NU author(s): Dr Piergiorgio Gentile, Dr Ana Ferreira-Duarte

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Abstract

In this review, different barrier membranes for guided bone regeneration (GBR) are described as a useful surgical technique to enhance bone regeneration in damaged alveolar sites before performing implants and fitting other dental appliances. The GBR procedure encourages bone regeneration through cellular exclusion and avoids the invasion of epithelial and connective tissues that grow at the defective site instead of bone tissue. The barrier membrane should satisfy various properties, such as biocompatibility, non-immunogenicity, non-toxicity, and a degradation rate that is long enough to permit mechanical support during bone formation. Other characteristics such as tissue integration, nutrient transfer, space maintenance and manageability are also of interest. In this review, various non-resorbable and resorbable commercially available membranes are described, based on expanded polytetrafluoroethylene, poly(lactic acid), poly(glycolic acid) and their copolymers. The polyester-based membranes are biodegradable, permit a single-stage procedure, and have higher manageability than non-resorbable membranes; however, they have shown poor biocompatibility. In contrast, membranes based on natural materials, such as collagen, are biocompatible but are characterized by poor mechanical properties and stability due to their early degradation. Moreover, new approaches are described, such as the use of multi-layered, graft-copolymer-based and composite membranes containing osteoconductive ceramic fillers as alternatives to conventional membranes


Publication metadata

Author(s): Gentile P, Chiono V, Tonda-Turo C, Ferreira AM, Ciardelli G

Publication type: Article

Publication status: Published

Journal: Biotechnology Journal

Year: 2011

Volume: 6

Issue: 10

Pages: 1187-1197

Print publication date: 01/10/2011

Online publication date: 20/09/2011

Acceptance date: 01/08/2011

ISSN (print): 1860-6768

ISSN (electronic): 1860-7314

Publisher: Wiley - VCH Verlag GmbH & Co. KGaA

URL: http://dx.doi.org/10.1002/biot.201100294

DOI: 10.1002/biot.201100294


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