Lookup NU author(s): Dr Sukhbinder Kumar,
Dr William Sedley,
Professor Tim Griffiths
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The physiological basis for musical hallucinations (MH) is not understood. One obstacle to understanding has been the lack of a method to manipulate the intensity of hallucination during the course of experiment. Residual inhibition, transient suppression of a phantom percept after the offset of a masking stimulus, has been used in the study of tinnitus. We report here a human subject whose MH were residually inhibited by short periods of music. Magnetoencephalography (MEG) allowed us to examine variation in the underlying oscillatory brain activity in different states. Source-space analysis capable of single-subject inference defined left-lateralised power increases, associated with stronger hallucinations, in the gamma band in left anterior superior temporal gyrus, and in the beta band in motor cortex and posteromedial cortex. The data indicate that these areas form a crucial network in the generation of MH, and are consistent with a model in which MH are generated by persistent reciprocal communication in a predictive coding hierarchy.
Author(s): Kumar S, Sedley W, Barnes GR, Teki S, Firston KJ, Griffiths TD
Publication type: Article
Publication status: Published
Print publication date: 01/03/2013
Online publication date: 16/12/2013
Acceptance date: 06/12/2013
ISSN (print): 0010-9452
ISSN (electronic): 1973-8102
Publisher: Edizioni Edra
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