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The expanding universe of disorders of the basal ganglia

Lookup NU author(s): Professor David Burn

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Abstract

The basal ganglia were originally thought to be associated purely with motor control. However, dysfunction and pathology of different regions and circuits are now known to give rise to many clinical manifestations beyond the association of basal ganglia dysfunction with movement disorders. Moreover, disorders that were thought to be caused by dysfunction of the basal ganglia only, such as Parkinson's disease and Huntington's disease, have diverse abnormalities distributed not only in the brain but also in the peripheral and autonomic nervous systems; this knowledge poses new questions and challenges. We discuss advances and the unanswered questions, and ways in which progress might be made.

Publication metadata

Author(s): Obeso JA, Rodriguez-Oroz MC, Stamelou M, Bhatia KP, Burn DJ

Publication type: Article

Publication status: Published

Journal: Lancet

Year: 2014

Volume: 384

Issue: 9942

Pages: 523-531

Print publication date: 09/08/2014

Online publication date: 18/06/2014

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group

URL: http://dx.doi.org/10.1016/S0140-6736(13)62418-6

DOI: 10.1016/S0140-6736(13)62418-6

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