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Lookup NU author(s): Dr Sasha Gartside
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Serotonin has a facilitatory role in the role of prolactin and adrenocorticotropin (ACTH) secretion. The serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) dose dependently (30-100 mg/kg i.p.) increased plasma prolactin and ACTH in the male rat. Prolactin and ACTH responses to 5-HTP (100 mg/kg) were attenuated by pretreatment with the non-selective 5-HT receptor antagonist, metergoline (0.5 mg/kg), and by the selective 5-HT2 receptor antagonists, ritanserin (0.4 mg/kg), ketanserin (2.5 mg/kg), ICI (5.0 mg/kg) and spiperone (1.0 mg/kg). The 5-HT1 receptor antagonists, propranolol (40 mg/kg) and pindolol (4.0 mg/kg), failed to antagonize the prolactin and ACTH responses to 5-HTP (100 mg/kg), as did the selective 5-HT3 receptor antagonist, BRL 43694 (1.0 mg/kg). The results suggest that the prolactin and ACTH responses to 5-HTP in the male rat are mediated by 5-HT2 receptors.
Author(s): Gartside SE, Cowen PJ
Publication type: Article
Publication status: Published
Journal: European Journal of Pharmacology
Year: 1990
Volume: 179
Issue: 1-2
Pages: 103-109
Print publication date: 10/04/1990
ISSN (print): 0014-2999
ISSN (electronic): 1879-0712
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/0014-2999(90)90407-W
DOI: 10.1016/0014-2999(90)90407-W
Notes: 0014-2999 (Print) Journal Article
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