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Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks

Lookup NU author(s): Dr Eva Lowther, Professor John O'Brien, Dr Michael Firbank, Professor Andrew Blamire

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Abstract

Resting state functional magnetic resonance imaging (fMRI) was used to measure whole brain functional connectivity within specific networks hypothesised to be more affected in dementia with Lewy bodies (DLB) (a disease characterised by prominent attentional deficits, spontaneous motor features of parkinsonism and depression) than in Alzheimer's disease (AD) and controls. This study involved 68 subjects (15 DLB, 13 AD and 40 controls) who were scanned using resting state BOLD (blood-oxygen-level-dependent) fMRI on a 3 T MRI scanner. Functional connectivity was measured using a model-free independent component analysis approach that consisted of temporally concatenating the resting state fMRI data of all study subjects and investigating group differences using a back-reconstruction procedure. Resting state functional connectivity was affected in the default mode, salience, executive and basal ganglia networks in DLB subjects compared with AD and controls. Functional connectivity was lower in DLB compared with AD and controls in these networks, except for the basal ganglia network, where connectivity was greater in DLB. No resting state networks showed less connectivity in AD compared with DLB or controls. Our results suggest that functional connectivity of resting state networks can identify differences between DLB and AD subjects that may help to explain why DLB subjects have more frequent attentional deficits, parkinsonian symptoms, and depression than those with AD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Lowther ER, O'Brien JT, Firbank MJ, Blamire AM

Publication type: Article

Publication status: Published

Journal: Psychiatry Research: Neuroimaging

Year: 2014

Volume: 223

Issue: 3

Pages: 192-201

Print publication date: 30/09/2014

Online publication date: 27/06/2014

Acceptance date: 19/06/2014

ISSN (print): 0925-4927

ISSN (electronic): 1872-7506

Publisher: Elsevier Ireland

URL: http://dx.doi.org/10.1016/j.pscychresns.2014.06.004

DOI: 10.1016/j.pscychresns.2014.06.004


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