Lookup NU author(s): Professor Christopher Petkov
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Auditory cortex (AC) contains several primary-like, or “core,” fields, which receive thalamic input and project to non-primary “belt” fields. In humans, the organization and layout of core and belt auditory fields are still poorly understood, and most auditory neuroimaging studies rely on macroanatomical criteria, rather than functional localization of distinct fields. A myeloarchitectonic method has beensuggested recently for distinguishing between core and belt fields in humans (Dick F, Tierney AT, Lutti A, Josephs O, Sereno MI, Weiskopf N. 2012. In vivo functional and myeloarchitectonic mapping of humanprimary auditory areas. J Neurosci. 32:16095–16105). We propose a marker for core AC based directly on functional magnetic resonance imaging (fMRI) data and pattern classification. We show that aportion of AC in Heschl’s gyrus classifies sound frequency more accurately than other regions in AC. Using fMRI data from macaques, we validate that the region where frequency classification performanceis significantly above chance overlaps core auditory fields, predominantly A1. Within this region, we measure tonotopic gradients and estimate the locations of the human homologues of the coreauditory subfields A1 and R. Our results provide a functional rather than anatomical localizer for core AC. We posit that inter-individual variability in the layout of core AC might explain disagreementsbetween results from previous neuroimaging and cytological studies.
Author(s): Schönwiesner M, Dechent P, Voit D, Petkov CI, Krumbholz K
Publication type: Article
Publication status: Published
Journal: Cerebral Cortex
Print publication date: 28/10/2014
Online publication date: 05/06/2014
Acceptance date: 01/01/1900
Date deposited: 10/12/2014
ISSN (print): 1047-3211
ISSN (electronic): 1460-2199
Publisher: Oxford University Press
PubMed id: 24904067
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