Lookup NU author(s): Dr Mary Slatter,
Professor Roderick Skinner
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Graft-versus-host disease (GvHD) remains a significant hurdle in overcoming the morbidity and mortality associated with haemopoietic stem cell transplantation in children. Better understanding of its pathobiology is facilitating the development of biomarkers for the severity of acute GvHD and treatment response, and has led to the introduction of a more prognostically relevant grading system for chronic GvHD. These enable stratification of appropriate prophylactic and treatment strategies according to the risk profiles of individual patients. Steroid-refractory acute GvHD has a poor prognosis, but early reports of the use of new immunosuppressive drugs and especially cellular treatments with extracorporeal photopheresis and mesenchymal stem cells suggest improved short-term outcomes and offer the promise of increased longer-term survival rates.
Author(s): Dhir S, Slatter M, Skinner R
Publication type: Review
Publication status: Published
Journal: Archives of Disease in Childhood
Print publication date: 01/12/2014
Online publication date: 12/07/2014
Acceptance date: 23/06/2014
ISSN (print): 0003-9888
ISSN (electronic): 1468-2044
Publisher: BMJ PUBLISHING GROUP