Lookup NU author(s): Dr Moritz von Stosch,
Dr Ronan O'Kennedy,
Professor Jarka Glassey
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
This report highlights the drivers, challenges, and enablers of the hybrid modeling applications in biopharmaceutical industry. It is a summary of an expert panel discussion of European academics and industrialists with relevant scientific and engineering backgrounds. Hybrid modeling is viewed in its broader sense, namely as the integration of different knowledge sources in form of parametric and nonparametric models into a hybrid semi-parametric model, for instance the integration of fundamental and data-driven models. A brief description of the current state-of-the-art and industrial uptake of the methodology is provided. The report concludes with a number of recommendations to facilitate further developments and a wider industrial application of this modeling approach. These recommendations are limited to further exploiting the benefits of this methodology within process analytical technology (PAT) applications in biopharmaceutical industry.
Author(s): von Stosch M, Davy S, Francois K, Galvanauskas V, Hamelink JM, Luebbert A, Mayer M, Oliveira R, O'Kennedy R, Rice P, Glassey J
Publication type: Article
Publication status: Published
Journal: Biotechnology Journal
Print publication date: 01/06/2014
Online publication date: 08/05/2014
Acceptance date: 01/04/2014
ISSN (print): 1860-6768
ISSN (electronic): 1860-7314
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