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Hybrid modeling for quality by design and PAT - benefits and challenges of applications in biopharmaceutical industry

Lookup NU author(s): Dr Moritz von Stosch, Dr Ronan O'Kennedy, Professor Jarka Glassey

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Abstract

This report highlights the drivers, challenges, and enablers of the hybrid modeling applications in biopharmaceutical industry. It is a summary of an expert panel discussion of European academics and industrialists with relevant scientific and engineering backgrounds. Hybrid modeling is viewed in its broader sense, namely as the integration of different knowledge sources in form of parametric and nonparametric models into a hybrid semi-parametric model, for instance the integration of fundamental and data-driven models. A brief description of the current state-of-the-art and industrial uptake of the methodology is provided. The report concludes with a number of recommendations to facilitate further developments and a wider industrial application of this modeling approach. These recommendations are limited to further exploiting the benefits of this methodology within process analytical technology (PAT) applications in biopharmaceutical industry.


Publication metadata

Author(s): von Stosch M, Davy S, Francois K, Galvanauskas V, Hamelink JM, Luebbert A, Mayer M, Oliveira R, O'Kennedy R, Rice P, Glassey J

Publication type: Article

Publication status: Published

Journal: Biotechnology Journal

Year: 2014

Volume: 9

Issue: 6

Pages: 719-726

Print publication date: 01/06/2014

Online publication date: 08/05/2014

Acceptance date: 01/04/2014

ISSN (print): 1860-6768

ISSN (electronic): 1860-7314

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1002/biot.201300385

DOI: 10.1002/biot.201300385


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