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Cognitive Impairment in Multiple System Atrophy: A Position Statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) Study Group

Lookup NU author(s): Professor David Burn

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Abstract

Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidencebased review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy. (C) 2014 International Parkinson and Movement Disorder Society


Publication metadata

Author(s): Stankovic I, Krismer F, Jesic A, Antonini A, Benke T, Brown RG, Burn DJ, Holton JL, Kaufmann H, Kostic VS, Ling H, Meissner WG, Poewe W, Semnic M, Seppi K, Takeda A, Weintraub D, Wenning GK, Movement Disorders Soc MSA MODIMSA

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2014

Volume: 29

Issue: 7

Pages: 857-867

Print publication date: 01/06/2014

Online publication date: 18/04/2014

Acceptance date: 10/02/2014

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/mds.25880

DOI: 10.1002/mds.25880


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Funding

Funder referenceFunder name
Dementia Biomedical Research Unit at South London, and Maudsley NHS Foundation Trust and King's College London
Multiple System Atrophy Trust
National Institute for Health Research University College London Hospitals Biomedical Research Centre
Reta Lila Weston Institute for Neurological Studies
National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre
F04404-B19Austrian Science Fund (FWF)

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