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Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations

Lookup NU author(s): Claire Schwab, Professor Christine Harrison

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Abstract

MYC translocations represent a genetic subtype of T-lineage acute lymphoblastic leukemia (T-ALL), which occurs at an incidence of similar to 6%, assessed within a cohort of 196 T-ALL patients (64 adults and 132 children). The translocations were of 2 types; those rearranged with the T-cell receptor loci and those with other partners. MYC translocations were significantly associated with the TAL/LMO subtype of T-ALL (P=.018) and trisomies 6 (P < .001) and 7 (P < .001). Within the TAL/LMO subtype, gene expression profiling identified 148 differentially expressed genes between patients with and without MYC translocations; specifically, 77 were upregulated and 71 downregulated in those with MYC translocations. The poor prognostic marker, CD44, was among the upregulated genes. MYC translocations occurred as secondary abnormalities, present in subclones in one-half of the cases. Longitudinal studies indicated an association with induction failure and relapse.


Publication metadata

Author(s): La Starza R, Borga C, Barba G, Pierini V, Schwab C, Matteucci C, Fernandez AGL, Leszl A, Cazzaniga G, Chiaretti S, Basso G, Harrison CJ, te Kronnie G, Mecucci C

Publication type: Article

Publication status: Published

Journal: Blood

Year: 2014

Volume: 124

Issue: 24

Pages: 3577-3582

Print publication date: 04/12/2014

Online publication date: 30/09/2014

Acceptance date: 12/09/2014

ISSN (print): 0006-4971

ISSN (electronic): 1528-0020

Publisher: American Society of Hematology

DOI: 10.1182/blood-2014-06-578856


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