Lookup NU author(s): Dr Arthur Pratt,
Professor John Isaacs
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Rheumatoid arthritis (RA) has long been recognised as a highly heterogeneous disease of immune dysregulation. Despite an ever-growing appreciation of the role of circulating autoantibodies in the development of 'seropositive' disease, the pathogenesis of seronegative RA remains poorly understood. Accumulating evidence suggests that RA 'serotypes', in fact, reflect distinct disease entities that, despite their clinical overlap, diverge in respect of genetic architecture, cellular pathology and even therapeutic responsiveness. Focussing on seronegative RA, this review considers these concepts and their implications for the management of patients with this challenging, though sometimes overlooked, condition. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.
Author(s): Pratt AG, Isaacs JD
Publication type: Review
Publication status: Published
Journal: Best Practice & Research Clinical Rheumatology
Print publication date: 01/08/2014
Online publication date: 18/11/2014
ISSN (print): 1521-6942
ISSN (electronic): 1521-1770