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Different forms of effective connectivity in primate frontotemporal pathways

Lookup NU author(s): Professor Christopher Petkov, Dr Yuki Kikuchi, Alice Milne

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of interconnected regions. Surprisingly, we find that, although certain earlier stages of auditory cortical processing can strongly activate frontal cortex, downstream auditory regions, such as voice-sensitive cortex, appear to functionally engage primarily an ipsilateral temporal lobe network. Stimulating other sites within this activated temporal lobe network shows strong activation of frontal cortex. The results indicate that the relative stage of sensory processing does not predict the level of functional access to the frontal lobes. Rather, certain brain regions engage local networks, only parts of which have a strong functional impact on frontal cortex.


Publication metadata

Author(s): Petkov CI, Kikuchi Y, Milne AE, Mishkin M, Rauschecker JP, Logothetis NK

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2015

Volume: 6

Print publication date: 01/01/2015

Online publication date: 23/01/2015

Acceptance date: 28/11/2014

ISSN (electronic): 2041-1723

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ncomms7000

DOI: 10.1038/ncomms7000


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