Lookup NU author(s): Dr Hannah Sinclair,
Dr Alan Bagnall,
Dr Vijay Kunadian
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After 2 decades of development and use in interventional cardiology research, optical coherence tomography (OCT) has now become a core intravascular imaging modality in clinical practice. Its unprecedented spatial resolution allows visualization of the key components of the atherosclerotic plaque that appear to confer "vulnerability" to rupture namely the thickness of the fibrous cap, size of the necrotic core, and the presence of macrophages. The utility of OCT in the evaluation of plaque composition can provide insights into the pathophysiology of acute coronary syndrome and the healing that occurs thereafter. A brief summary of the principles of OCT technology and a comparison with other intravascular imaging modalities is presented. The review focuses on the current evidence for the use of OCT in identifying vulnerable plaques in acute coronary syndrome and its limitations. (C) 2015 by the American College of Cardiology Foundation.
Author(s): Sinclair H, Bourantas C, Bagnall A, Mintz GS, Kunadian V
Publication type: Article
Publication status: Published
Journal: JACC-Cardiovascular Imaging
Print publication date: 01/02/2015
Online publication date: 09/02/2015
Acceptance date: 09/12/2014
ISSN (print): 1936-878X
ISSN (electronic): 1876-7591
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