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No one metric is likely to capture an activity as complex, or as uncertain, as R&D. In fact, the pursuit of any one metric to the exclusion of all others is likely to sub-optimize the entire research and development process. This paper outlines the devastating impact that the single minded pursuit of cycle time reduction had on the pharmaceutical industry. Maximising development speed through cycle time reduction clogged the development pipeline with marginal or failing medicines, increased late-stage attrition, increased R&D costs, and paradoxically reduced R&D productivity. The industry became really slick at delivering late-stage failures to the market place.
Author(s): Lendrem DW
Publication type: Article
Publication status: Published
Journal: Chemistry World
Print publication date: 25/03/2015
Online publication date: 25/03/2015
Acceptance date: 25/03/2015
ISSN (print): 1473-7604
ISSN (electronic): 1749-5318
Publisher: Royal Society of Chemistry