Lookup NU author(s): Dr Teresa Ndlovu,
Emeritus Professor Alan Ward,
Professor Jarka Glassey,
Professor Galip Akay
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A novel functionalized micro-porous matrix was developed with well-controlled physicochemical proprieties such as pore size and surface chemistry. The matrix was used as a solid support in the growth of "Streptomyces coelicolor" A3(2) to enhance the production of antibiotics. The results shown support a higher production of prodigiosin and actinorhodin with overall production increase of 2-5 and 6-17, respectively, compared to conventional submerged liquid culture, offering a potential improvement in volumetric productivity. Scanning Electron Microscopy was used to evaluate pore size as well as bacterial adhesion, penetration, proliferation and migration within the micro-porous matrix. (C) 2015 Elsevier B.V. All rights reserved.
Author(s): Ndlovu TM, Ward AC, Glassey J, Eskildsen J, Akay G
Publication type: Article
Publication status: Published
Journal: Materials Science and Engineering C: Materials for Biological Applications
Print publication date: 01/04/2015
Online publication date: 16/01/2015
Acceptance date: 14/01/2015
ISSN (print): 0928-4931
ISSN (electronic): 1873-0191
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