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Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Lookup NU author(s): Professor Rita Horvath, Professor Patrick Chinnery

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Abstract

Protein synthesis is critically dependent on transfer (t)-RNAs, but the factors regulating tRNA function are poorly understood. In this issue of Cell Metabolism, Wei et al. (2015) show that Cdk5 regulatory subunit-associated protein-like-1 synchronizes mitochondrial and cytosolic translation in response to external stress, providing key insight into the pathogenesis of a common inherited mitochondrial disease.


Publication metadata

Author(s): Horvath R, Chinnery PF

Publication type: Editorial

Publication status: Published

Journal: Cell Metabolism

Year: 2015

Volume: 21

Issue: 3

Pages: 351-352

Print publication date: 03/03/2015

Online publication date: 03/03/2015

ISSN (print): 1550-4131

ISSN (electronic): 1932-7420

Publisher: Cell Press

URL: http://dx.doi.org/10.1016/j.cmet.2015.02.012

DOI: 10.1016/j.cmet.2015.02.012


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