Lookup NU author(s): Bian Zhang,
Professor Bernard Golding,
Dr Ian Hardcastle
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Potent and selective small-molecule inhibitors of the p53-MDM2 interaction intended for the treatment of p53 wild-type tumors have been designed and optimized in a number of chemical series. This review details recent disclosures of compounds in advanced optimization and features key series that have given rise to clinical trial candidates. The structure–activity relationships for inhibitor classes are discussed with reference to x-ray structures, and common structural features are identified.
Author(s): Zhang B, Golding BT, Hardcastle IR
Publication type: Review
Publication status: Published
Journal: Future Medicinal Chemistry
Print publication date: 01/04/2015
Acceptance date: 01/01/1900
ISSN (print): 1756-8919
ISSN (electronic): 1756-8927