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Deubiquitinating enzymes as oncotargets.

Lookup NU author(s): Dr Urszula McClurg, Professor Craig Robson

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics. Epigenetic processes are regulated by post-translational modifications including ubiquitination which can directly affect either histones or transcription factors or may target their co-factors and interacting partners exerting an indirect effect. Deubiquitination of these target proteins is equally important and alterations in this pathway can also lead to cancer development, progression and metastasis. Only the correct, unaltered balance between ubiquitination and deubiquitination ensures healthy cellular homeostasis. In this review we focus on the role of deubiquitinating (DUB) enzymes in various aspects of epigenetics including the regulation of transcription factors, histone modifications, DNA damage repair pathways and cell cycle regulation. We discuss the impact of those processes on tumourigenesis and potential therapeutic applications of DUBs for cancer treatment.


Publication metadata

Author(s): McClurg UL, Robson CN

Publication type: Article

Publication status: Published

Journal: Oncotarget

Year: 2015

Volume: 6

Issue: 12

Pages: 9657-9668

Print publication date: 23/04/2015

Online publication date: 23/04/2015

Acceptance date: 08/04/2015

Date deposited: 26/05/2015

ISSN (electronic): 1949-2553

Publisher: Impact Journals

URL: http://doi.org/10.18632/oncotarget.3922

DOI: 10.18632/oncotarget.3922

PubMed id: 25962961


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