Lookup NU author(s): Dr Luis Peraza Rodriguez,
Professor John-Paul Taylor,
Professor Marcus Kaiser
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The clinical phenotype of dementia with Lewy bodies (DLB) is different from Alzheimer’s Disease (AD), suggesting a divergence between these diseases in terms of brain network organisation. To fully understand this, we studied functional networks from resting state functional magnetic resonance imaging (rs-fMRI) in cognitively matched DLB and AD patients. The DLB group demonstrated a generalized lower synchronization compared to the AD and healthy controls, and this was more severe for edges connecting distant brain regions. Global network measures were significantly different between DLB and AD. For instance, AD showed lower small-worldness than healthy controls, while DLB showed higher small-worldness (AD<controls<DLB), and this was also the case for global efficiency (DLB>controls>AD) and clustering coefficient (DLB<controls<AD). Differences were also found for nodal measures at brain regions associated with each disease. Finally, we found significant associations between network performance measures and global cognitive impairment and severity of cognitive fluctuations in DLB. These results show network divergences between DLB and AD which appear to reflect their neuropathological differences.
Author(s): Peraza LR, Taylor J-P, Kaiser M
Publication type: Article
Publication status: Published
Journal: Neurobiology of Aging
Print publication date: 01/09/2015
Online publication date: 01/06/2015
Acceptance date: 23/05/2015
ISSN (print): 0197-4580
ISSN (electronic): 1558-1497
PubMed id: 26115566
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