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Gaze-Dependent Topography in Human Posterior Parietal Cortex

Lookup NU author(s): Dr Jason Connolly, Dr Quoc Vuong, Professor Alexander Thiele

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

The brain must convert retinal coordinates into those required for directing an effector. One prominent theory holds that, through a combination of visual and motor/proprioceptive information, head-/body-centered representations are computed within the posterior parietal cortex (PPC). An alternative theory, supported by recent visual and saccade functional magnetic resonance imaging (fMRI) topographic mapping studies, suggests that PPC neurons provide a retinal/eye-centered coordinate system, in which the coding of a visual stimulus location and/or intended saccade endpoints should remain unaffected by changes in gaze position. To distinguish between a retinal/eye-centered and a head-/body-centered coordinate system, we measured how gaze direction affected the representation of visual space in the parietal cortex using fMRI. Subjects performed memory-guided saccades from a central starting point to locations "around the clock." Starting points varied between left, central, and right gaze relative to the head-/body midline. We found that memory-guided saccadotopic maps throughout the PPC showed spatial reorganization with very subtle changes in starting gaze position, despite constant retinal input and eye movement metrics. Such a systematic shift is inconsistent with models arguing for a retinal/eye-centered coordinate system in the PPC, but it is consistent with head-/body-centered coordinate representations.


Publication metadata

Author(s): Connolly JD, Vuong QC, Thiele A

Publication type: Article

Publication status: Published

Journal: Cerebral Cortex

Year: 2015

Volume: 25

Issue: 6

Pages: 1519-1526

Print publication date: 01/06/2015

Online publication date: 18/12/2013

Date deposited: 07/07/2015

ISSN (print): 1047-3211

ISSN (electronic): 1460-2199

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/cercor/bht344

DOI: 10.1093/cercor/bht344

PubMed id: PMC4428299


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