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We propose an automaton, a theoretical framework that demonstrates how to improve the yield of the synthesis of branched chemical polymer reactions. This is achieved by separating substeps of the path of synthesis into compartments. We use chemical containers (chemtainers) to carry the substances through a sequence of fixed successive compartments. We describe the automaton in mathematical terms and show how it can be configured automatically in order to synthesize a given branched polymer target. The algorithm we present finds an optimal path of synthesis in linear time. We discuss how the automaton models compartmentalized structures found in cells, such as the endoplasmic reticulum and the Golgi apparatus, and we show how this compartmentalization can be exploited for the synthesis of branched polymers such as oligosaccharides. Lastly, we show examples of artificial branched polymers and discuss how the automaton can be configured to synthesize them with maximal yield.
Author(s): Weyland M, Fellermann H, Hadorn M, Sorek D, Lancet D, Rasmussen S, Füchslin RM
Publication type: Article
Publication status: Published
Journal: Computational and Mathematical Methods in Medicine
Year: 2013
Volume: 2013
Online publication date: 08/12/2013
Acceptance date: 08/12/2013
Publisher: Hindawi Publishing Corporation
URL: http://dx.doi.org/10.1155/2013/467428
DOI: 10.1155/2013/467428
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