Lookup NU author(s): Angelica Mariani,
Dr Mandeep Atwal,
Professor Caroline Austin
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The TOP2 poison etoposide has been implicated in the generation of secondary malignancies during cancer treatment. Structural similarities between TOP2 isoforms challenge the rational design of isoform-specific poisons to further delineate these processes. Herein, we describe the synthesis and biological evaluation of a focused library of etoposide analogues, with the identification of two novel small molecules exhibiting TOP2B-dependent toxicity. Our findings pave the way toward studying isoform-specific cellular processes by means of small molecule intervention.
Author(s): Mariani A, Bartoli A, Atwal M, Lee KC, Austin CA, Rodriguez R
Publication type: Article
Publication status: Published
Journal: Journal of Medicinal Chemistry
Print publication date: 11/06/2015
Online publication date: 06/05/2015
ISSN (print): 0022-2623
ISSN (electronic): 1520-4804
Publisher: American Chemical Society
Altmetrics provided by Altmetric