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Effects of transcranial direct current stimulation upon attention and visuoperceptual function in Lewy body dementia: a preliminary study

Lookup NU author(s): Dr Greg Elder, Dr Michael Firbank, Professor John-Paul Taylor

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

ABSTRACTBackground: Individuals with Lewy body dementia (LBD) typically exhibit impairments in attentional and executive function. Current pharmacological treatments have limited efficacy, with associated side effects. Transcranial direct current stimulation (tDCS) may represent an alternative treatment, as cognitive improvements have been demonstrated in healthy individuals. However, no studies to date have assessed the feasibility of tDCS in an LBD population. The aim of this preliminary study, therefore, was to assess the tolerability of tDCS, as well as its effects upon attentional and visuoperceptual performance, in LBD patients.Methods: Thirteen participants completed attentional (simple reaction time, choice reaction time, and digit vigilance) and forced-choice visuoperceptual (angle and motion perception) tasks before and after one 20-min session of active tDCS (0.08 mA/cm2). The anodal electrode was applied to the left dorsolateral prefrontal cortex and the cathodal electrode was applied to the right deltoid. Attentional (task accuracy and reaction time to correct answers) and visuoperceptual (task accuracy and difficulty) outcome measures were compared using paired t-tests.Results: All participants tolerated stimulation and did not report any side effects during or immediately after stimulation. Post-stimulation improvements were observed in the choice reaction time (increased percentage of correct answers; p = 0.01) and digit vigilance (reduced mean reaction time to correct answers; p = 0.02) attention tasks. Visuoperceptual task performance did not improve (all p-values > 0.05).Conclusions: Attentional, but not visuoperceptual, improvements were observed following stimulation in LBD patients. Larger-scale, placebo-controlled trials are needed to confirm whether tDCS is a useful treatment option for attentional deficits in LBD.


Publication metadata

Author(s): Elder GJ, Firbank MJ, Kumar H, Chatterjee P, Chakraborty T, Dutt A, Taylor J-P

Publication type: Article

Publication status: Published

Journal: International Psychogeriatrics

Year: 2016

Volume: 28

Issue: 02

Pages: 341-347

Print publication date: 01/02/2016

Online publication date: 07/08/2015

Acceptance date: 27/06/2015

Date deposited: 12/08/2015

ISSN (print): 1041-6102

ISSN (electronic): 1741-203X

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S1041610215001180

DOI: 10.1017/S1041610215001180

PubMed id: 26250473


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