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An Improved Method for Difluorocyclopropanation of Alkenes

Lookup NU author(s): Professor Mike Waring

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Abstract

Difluorocyclopropanation of alkenes using fluorinated acetate salts using convential heating is often a slow, inefficient, and energy-intensive process. We report here a modified protocol which enables the rapid (<5 min) preparation of 1,1-difluorocyclopropanes, using microwave irradiation. The new procedure is not only considerably faster than previously reported methods, but it also employs easily removed, low boiling-point solvents and avoids the use of highly toxic or ozone-depleting substances.


Publication metadata

Author(s): Gill DM, McLay N, Waring MJ, Wilkinson CT, Sweeney JB

Publication type: Article

Publication status: Published

Journal: Synlett

Year: 2014

Volume: 25

Issue: 12

Pages: 1756-1756

Online publication date: 26/06/2014

Acceptance date: 14/03/2014

ISSN (print): 0936-5214

ISSN (electronic): 1437-2096

Publisher: Georg Thieme Verlag

URL: http://dx.doi.org/10.1055/s-0033-1341155

DOI: 10.1055/s-0033-1341155


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