Lookup NU author(s): Professor Mike Waring
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A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable in vivo probe compound, which was confirmed to exhibit pharmacology consistent with GPR40 antagonism.
Author(s): Waring MJ, Baker DJ, Bennett SNL, Dossetter AG, Fenwick M, Garcia R, Georgsson J, Groombridge SD, Loxham S, MacFaul PA, Maskill KG, Morgan D, Morrell J, Pointon H, Robb GR, Smith DM, Stokes S, Wilkinson G
Publication type: Article
Publication status: Published
Print publication date: 01/06/2015
Online publication date: 08/04/2015
Acceptance date: 01/04/2015
ISSN (print): 2040-2503
ISSN (electronic): 2040-2511
Publisher: Royal Society of Chemistry
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