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Peptide Amphiphiles in Corneal Tissue Engineering

Lookup NU author(s): Martina Miotto, Dr Ricardo Martins Gouveia, Professor Che Connon

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

The increasing interest in effort towards creating alternative therapies have led to exciting breakthroughs in the attempt to bio-fabricate and engineer live tissues. This has been particularly evident in the development of new approaches applied to reconstruct corneal tissue. The need for tissue-engineered corneas is largely a response to the shortage of donor tissue and the lack of suitable alternative biological scaffolds preventing the treatment of millions of blind people worldwide. This review is focused on recent developments in corneal tissue engineering, specifically on the use of self-assembling peptide amphiphiles for this purpose. Recently, peptide amphiphiles have generated great interest as therapeutic molecules, both in vitro and in vivo. Here we introduce this rapidly developing field, and examine innovative applications of peptide amphiphiles to create natural bio-prosthetic corneal tissue in vitro. The advantages of peptide amphiphiles over other biomaterials, namely their wide range of functions and applications, versatility, and transferability are also discussed to better understand how these fascinating molecules can help solve current challenges in corneal regeneration.


Publication metadata

Author(s): Miotto M, Gouveia RM, Connon CJ

Publication type: Article

Publication status: Published

Journal: Journal of Functional Biomaterials

Year: 2015

Volume: 6

Issue: 3

Pages: 687-707

Online publication date: 06/08/2015

Acceptance date: 03/08/2015

ISSN (electronic): 2079-4983

Publisher: MDPI

URL: http://dx.doi.org/10.3390/jfb6030687

DOI: 10.3390/jfb6030687


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