Lookup NU author(s): Dr Muhammad Raza,
Dr Desa Lilic
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Chronic mucocutaneous candidiasis (CMC) is a primary immunodeficiency disorder characterised by susceptibility to chronic Candida and fungal dermatophyte infections of the skin, nails and mucous membranes. Molecular epidemiology studies of CMC infection are limited in number and scope and it is not clear whether single or multiple strains inducing CMC persist stably or are exchanged and replaced.We sequenced for multi locus sequence typing (MLST) 42 C. albicans colonies from 6 unrelated CMC patients; multiple colonies were typed from swabs taken from multiple body sites across multiple time points over a 17 month period. Among isolates from each individual patient, our data show clonal and persistent sequence types that were stable over time, identical between multiple infection sites and exhibit azole resistant phenotypes. No shared origin or common source of infection is identified among isolates from these patients. Additionally we performed C. albicans MLST SNP genotype frequency analysis suggestive of a preponderance of previous loss of heterozygosity (LOH) events among persistent and azole resistant colonisers of patients with autoimmune disorders.
Author(s): Moorhouse AJ, Renisson C, Raza M, Lilic D, Gow NAR
Publication type: Article
Publication status: Published
Journal: PLoS One
Online publication date: 05/02/2016
Acceptance date: 09/12/2015
Date deposited: 11/03/2016
ISSN (electronic): 1932-6203
Publisher: Public Library of Science
PubMed id: 26849050
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