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Anticholinergic Load: Is there a Cognitive Cost in Early Parkinson's Disease?

Lookup NU author(s): Professor Alison Yarnall, Dr Rachael LawsonORCiD, Dr Gordon Duncan, Dr Tien Kheng Khoo, Professor David BrooksORCiD, Professor John-Paul TaylorORCiD, Professor David Burn

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Abstract

We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores were not significantly different. Cognitive scores did not differ in PD participants taking medications with anticholinergic activity compared to those who were not. Low overall ADS scores due to increased awareness of adverse effects of medications and brevity of follow-up are potential explanations

Publication metadata

Author(s): Yarnall AJ, Lawson RA, Duncan GW, Breen DP, Khoo TK, Brooks D, Barker RA, Taylor JP, Burn DJ

Publication type: Article

Publication status: Published

Journal: Journal of Parkinson's Disease

Year: 2015

Volume: 5

Issue: 4

Pages: 743-743

Print publication date: 02/10/2015

Acceptance date: 01/01/1900

ISSN (print): 1877-7171

ISSN (electronic): 1877-718X

Publisher: IOS Press

URL: http://dx.doi.org/10.3233/JPD-150664

DOI: 10.3233/JPD-150664

PubMed id: 26444094

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