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Depressive symptoms are associated with daytime sleepiness and subjective sleep quality in dementia with Lewy bodies

Lookup NU author(s): Dr Greg Elder, Dr Sean Colloby, Debbie Lett, Professor John O'Brien, Dr Kirstie Anderson, Professor David Burn, Professor Ian McKeith, Professor John-Paul Taylor

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Objective: Sleep problems and depression are common symptoms in dementia with Lewy bodies (DLB), where patients typically experience subjectively poor sleep quality, fatigue and excessive daytime sleepiness. However, whilst sleep disturbances have been linked to depression, this relationship has not received much attention in DLB. The present cross-sectional study addresses this by examining whether depressive symptoms are specifically associated with subjective sleep quality and daytime sleepiness in DLB, and by examining other contributory factors. Methods: DLB patients (n = 32) completed the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and the 15-item Geriatric Depression Scale (GDS-15). Motor and cognitive functioning was also assessed. Pearson correlations were used to assess the relationship between GDS-15, ESS and PSQI scores. Results: GDS-15 scores were positively associated with both ESS (r = .51, p < .01) and PSQI (r = .59, p < .001) scores. Conclusions: Subjective poor sleep and daytime sleepiness were associated with depressive symptoms in DLB. Given the cross-sectional nature of the present study, the directionality of this relationship cannot be determined, although this association did not appear to be mediated by sleep quality or daytime sleepiness. Nevertheless, these findings have clinical relevance; daytime sleepiness or poor sleep quality might indicate depression in DLB, and subsequent work should examine whether the treatment of depression can reduce excessive daytime sleepiness and improve sleep quality in DLB patients. Alternatively, more rigorous screening for sleep problems in DLB might assist the treatment of depression.


Publication metadata

Author(s): Elder GJ, Colloby SJ, Lett DJ, O'Brien JT, Anderson KN, Burn DJ, McKeith IG, Taylor JP

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2016

Volume: 31

Issue: 7

Pages: 765-770

Print publication date: 01/07/2016

Online publication date: 11/11/2015

Acceptance date: 14/10/2015

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/gps.4389

DOI: 10.1002/gps.4389

PubMed id: 26560190


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