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Lookup NU author(s): Dr Chien-Yi ChangORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Bacteria sense their own population size, tune the expression of responding genes, and behave accordingly to environmental stimuli by secreting signaling molecules. This phenomenon is termed as quorum sensing (QS). By exogenously manipulating the signal transduction bacterial population behaviors could be controlled, which may be done through quorum quenching (QQ). QS related regulatory networks have been proven their involvement in regulating many virulence determinants in pathogenic bacteria in the course of infections. Interfering with QS signaling system could be a novel strategy against bacterial infections and therefore requires more understanding of their fundamental mechanisms. Here we review the development of studies specifically on the inhibition of production of N-acyl-homoserine lactone (AHL), a common proteobacterial QS signal. The opportunistic pathogen, Pseudomonas aeruginosa, equips the alkylquinolone (AQ)-mediated QS which also plays crucial roles in its pathogenicity. The studies in QQ targeting on AQ are also discussed.
Author(s): Chan KG, Liu YC, Chang CY
Publication type: Review
Publication status: Published
Journal: Frontiers in Microbiology
Year: 2015
Volume: 6
Online publication date: 19/10/2015
Acceptance date: 09/10/2015
ISSN (electronic): 1664-302X
Publisher: FRONTIERS MEDIA SA
URL: http://dx.doi.org/10.3389/fmicb.2015.01173
DOI: 10.3389/fmicb.2015.01173
