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An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering

Lookup NU author(s): Dr Piergiorgio Gentile

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Abstract

Poly(lactic-co-glycolic) acid (PLGA) has attracted considerable interest as a base material for biomedical applications due to its: (i) biocompatibility; (ii) tailored biodegradation rate (depending on the molecular weight and copolymer ratio); (iii) approval for clinical use in humans by the U.S. Food and Drug Administration (FDA); (iv) potential to modify surface properties to provide better interaction with biological materials; and (v) suitability for export to countries and cultures where implantation of animal-derived products is unpopular. This paper critically reviews the scientific challenge of manufacturing PLGA-based materials with suitable properties and shapes for specific biomedical applications, with special emphasis on bone tissue engineering. The analysis of the state of the art in the field reveals the presence of current innovative techniques for scaffolds and material manufacturing that are currently opening the way to prepare biomimetic PLGA substrates able to modulate cell interaction for improved substitution, restoration, or enhancement of bone tissue function.


Publication metadata

Author(s): Gentile P, Chiono V, Carmagnola I, Hatton PV

Publication type: Review

Publication status: Published

Journal: International Journal of Molecular Sciences

Year: 2014

Volume: 15

Issue: 3

Pages: 3640-3659

Print publication date: 28/02/2014

Online publication date: 28/02/2014

Acceptance date: 20/02/2014

ISSN (print): 1661-6596

ISSN (electronic): 1422-0067

URL: http://www.mdpi.com/1422-0067/15/3/3640

DOI: 10.3390/ijms15033640


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