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Poly(lactic acid)-based blends with tailored physicochemical properties for tissue engineering applications: a case study

Lookup NU author(s): Dr Piergiorgio Gentile

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Abstract

Binary blends of poly(L-lactic) acid (PLLA: 201790 Da) and poly(lactide-co-glycolide) (PLGA) (LA:GA = 50:50 mol:mol; 32030 Da) with various compositions were prepared. Physicochemical properties of PLLA/PLGA blends were analyzed. Blends showed a biphasic morphology, with distinct glass transition temperatures, which only slightly approximated compared to pure polymers. Analysis of tensile mechanical properties through the Kerner-Uemura-Takayanagi model showed compatibility for PLLA/PLGA 75/25 blend. Rapid degradation of PLGA phase (2–8 weeks) in PLLA/PLGA 75/25 blend led to porous samples, which appear promising for drug delivery and tissue engineering. A limited inflammatory reaction resulted from subcutaneous implantation of PLLA/PLGA 75/25 in Balb-c mice.


Publication metadata

Author(s): Carmagnola I, Nardo T, Gentile P, Tonda-Turo C, Mattu C, Cabodi S, Defilippi P, Chiono V

Publication type: Article

Publication status: Published

Journal: International Journal of Polymeric Materials and Polymeric Biomaterials

Year: 2014

Volume: 64

Issue: 2

Pages: 90-98

Print publication date: 16/10/2014

Online publication date: 16/10/2014

Acceptance date: 19/01/2014

ISSN (print): 0091-4037

ISSN (electronic): 1563-535X

Publisher: Taylor & Francis Inc.

URL: http://www.tandfonline.com/doi/abs/10.1080/00914037.2014.886247?journalCode=gpom20

DOI: 10.1080/00914037.2014.886247


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