Lookup NU author(s): Dr Piergiorgio Gentile
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Binary blends of poly(L-lactic) acid (PLLA: 201790 Da) and poly(lactide-co-glycolide) (PLGA) (LA:GA = 50:50 mol:mol; 32030 Da) with various compositions were prepared. Physicochemical properties of PLLA/PLGA blends were analyzed. Blends showed a biphasic morphology, with distinct glass transition temperatures, which only slightly approximated compared to pure polymers. Analysis of tensile mechanical properties through the Kerner-Uemura-Takayanagi model showed compatibility for PLLA/PLGA 75/25 blend. Rapid degradation of PLGA phase (2–8 weeks) in PLLA/PLGA 75/25 blend led to porous samples, which appear promising for drug delivery and tissue engineering. A limited inflammatory reaction resulted from subcutaneous implantation of PLLA/PLGA 75/25 in Balb-c mice.
Author(s): Carmagnola I, Nardo T, Gentile P, Tonda-Turo C, Mattu C, Cabodi S, Defilippi P, Chiono V
Publication type: Article
Publication status: Published
Journal: International Journal of Polymeric Materials and Polymeric Biomaterials
Print publication date: 16/10/2014
Online publication date: 16/10/2014
Acceptance date: 19/01/2014
ISSN (print): 0091-4037
ISSN (electronic): 1563-535X
Publisher: Taylor & Francis Inc.
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