Lookup NU author(s): Dr Piergiorgio Gentile
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Gelatin (GL) nanofibrous matrices mimicking the complex biological structure of the natural extracellular matrix (ECM) were prepared from aqueous solutions by electrospinning technique. GL nanofibres with a diameter size of around 300nm were obtained optimising the process and solution parameters. To increase the GL stability in aqueous environment γ-glycidoxypropyltrimethoxysilane (GPTMS) was used as GL crosslinker. GPTMS crosslinking did not modify the nanofibrous matrix morphology: fibre diameter and membrane pores size were 327±45 nm and 1.64±0.37 μm, respectively. The produced GPTMS crosslinked GL nanofibres (GL/GPTMS_NF) were found to support the in vitro adhesion, proliferation and survival of neonatal olfactory bulb ensheating cells (NOBECs).
Author(s): Tonda-Turo C, Cipriani E, Gnavi S, Chiono V, Mattu C, Gentile P, Perroteau I, Zanetti M, Ciardelli G
Publication type: Article
Publication status: Published
Journal: Materials Science and Engineering C
Print publication date: 01/07/2013
Online publication date: 28/02/2013
Acceptance date: 20/02/2013
ISSN (electronic): 0928-4931
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