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The role of glycans in the development and progression of prostate cancer

Lookup NU author(s): Dr Jennifer Munkley, Professor David Elliott

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Nature Publishing Group, 2016.

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Abstract

Prostate cancer is a unique and heterogeneous disease. Currently, a major unmet clinical need exists to develop biomarkers that enable indolent disease to be distinguished from aggressive disease. The prostate is an abundant secretor of glycoproteins of all types, and alterations in glycans are, therefore, attractive as potential biomarkers and therapeutic targets. Despite progress over the past decade in profiling the genome and proteome, the prostate cancer glycoproteome remains relatively understudied. A wide range of alterations in the glycoproteins on prostate cancer cells can occur, including increased sialylation and fucosylation, increased O-beta-N-acetylglucosamine (GlcNAc) conjugation, the emergence of cryptic and high-mannose N-glycans and alterations to proteoglycans. Glycosylation can alter protein function and has a key role in many important biological processes in cancer including cell adhesion, migration, interactions with the cell matrix, immune surveillance, cell signalling and cellular metabolism; altered glycosylation in prostate cancer might modify some, or all of these processes. In the past three years, powerful tools such as glycosylation-specific antibodies and glycosylation gene signatures have been developed, which enable detailed analyses of changes in glycosylation. Thus, emerging data on these often overlooked modifications have the potential to improve risk stratification and therapeutic strategies in patients with prostate cancer.


Publication metadata

Author(s): Munkley J, Mills IG, Elliott DJ

Publication type: Article

Publication status: Published

Journal: Nature Reviews Urology

Year: 2016

Volume: 13

Issue: 6

Pages: 324-333

Print publication date: 01/06/2016

Online publication date: 19/04/2016

Acceptance date: 12/01/2016

Date deposited: 20/05/2016

ISSN (print): 1759-4812

ISSN (electronic): 1759-4820

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/nrurol.2016.65

DOI: 10.1038/nrurol.2016.65


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