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Cognitive impairment in Parkinson's disease: impact on quality of life carers

Lookup NU author(s): Dr Rachael Lawson, Dr Alison Yarnall, Dr Fionnuala Johnston, Dr Gordon Duncan, Dr Tien Khoo, Daniel Collerton, Professor John-Paul Taylor, Professor David Burn

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

BackgroundThe quality of life (QoL) of informal caregivers of people with Parkinson’s disease (PwP) can be affected by the caring role. Due to cognitive symptoms and diminished activities of daily living, in addition to the management of motor symptoms, carers of PwP and cognitive impairment may experience increased levels of burden and poorer QoL compared to carers of PwP without cognitive impairment. This study aimed to investigate the impact of cognitive impairment in PD upon QoL of carers.MethodsApproximately 36 months after diagnosis 66 dyadic couples of PwP and carers completed assessments. PwP completed a schedule of neuropsychological assessments and QoL measures; carers of PwP completed demographic questionnaires and assessments of QoL. Factor scores of attention, memory/executive function, and global cognition, as derived by principal component analysis, were used to evaluate cognitive domains.ResultsHierarchical regression analysis found lower Montreal Cognitive Assessment (MoCA) was a significant independent predictor of poorer carer QoL, in addition to number of hours spent caregiving, carer depression and PD motor severity. Attentional deficits accounted for the largest proportion of variance of carer QoL. Carers of PwP and dementia (PDD) (n=9) had significantly poorer QoL scores compared with PwP and mild cognitive impairment (n=18) or normal cognition (n=39) carers (p<0.01).ConclusionsAttentional deficits were the strongest predictor of carer QoL compared to other cognitive predictors. Carers for those with PDD reported the poorest QoL. Interventions such as respite or cognitive behavioural therapy to improve mood and self-efficacy in carers may improve carer QoL.


Publication metadata

Author(s): Lawson RA, Yarnall AJ, Johnston F, Duncan GW, Khoo TK, Collerton D, Taylor JP, Burn DJ, on behalf of the ICICLE-PD study group

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2017

Volume: 32

Issue: 12

Pages: 1362-1370

Print publication date: 01/12/2017

Online publication date: 07/12/2016

Acceptance date: 19/10/2016

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: John Wiley & Sons Ltd

URL: http://dx.doi.org/10.1002/gps.4623

DOI: 10.1002/gps.4623


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