Lookup NU author(s): Dr Simon Bomken,
Dr Nicholas Bown,
Dr Peter Carey,
Dr Katrina Wood,
Dr Kevin Windebank
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Hypereosinophilia is a rare phenomenon associated with childhood malignancy, predominantly acute lymphoblastic leukaemia. Causation is unclear and likely to have multiple mechanisms. We report a six year old boy presenting with hypereosinophilia and associated Loeffler endocarditis. Three months following his initial hypereosinophilia he developed cutaneous B-lymphoblastic lymphoma. Re-analysis of apparently uninvolved bone marrow, taken at initial presentation, revealed a single, previously unidentified, t(5;14)(q31;q32) positive cell. Using fluorescent in situ hybridisation, we demonstrate IL3/IgH@ fusion in cutaneous lymphoma cells. Our case confirms the association of hypereosinophilia and B-lymphoblastic lymphoma and strengthens the association between IL3 hypersecretion and hypereosinophilia. Pediatr Blood Cancer 2015;62:1055-1057. (c) 2014 Wiley Periodicals, Inc.
Author(s): Bomken S, Haigh S, Bown N, Carey P, Wood K, Windebank K
Publication type: Article
Publication status: Published
Journal: Pediatric Blood & Cancer
Print publication date: 01/06/2015
Online publication date: 08/11/2014
Acceptance date: 23/09/2014
ISSN (print): 1545-5009
ISSN (electronic): 1545-5017
Publisher: John Wiley & Sons, Inc.
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