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Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity

Lookup NU author(s): Dr Mario Siervo

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Abstract

Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5-day baseline diet in 19 adults with obesity confined to a metabolic ward where they exercised daily. Subjects received both isocaloric diets in random order during each of two inpatient stays. Body fat loss was calculated as the difference between daily fat intake and net fat oxidation measured while residing in a metabolic chamber. Whereas carbohydrate restriction led to sustained increases in fat oxidation and loss of 53 +/- 6 g/day of body fat, fat oxidation was unchanged by fat restriction, leading to 89 +/- 6 g/day of fat loss, and was significantly greater than carbohydrate restriction (p = 0.002). Mathematical model simulations agreed with these data, but predicted that the body acts to minimize body fat differences with prolonged isocaloric diets varying in carbohydrate and fat.


Publication metadata

Author(s): Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L

Publication type: Article

Publication status: Published

Journal: Cell Metabolism

Year: 2015

Volume: 22

Issue: 3

Pages: 427-436

Print publication date: 01/09/2015

Online publication date: 13/08/2015

Acceptance date: 23/07/2015

ISSN (print): 1550-4131

ISSN (electronic): 1932-7420

Publisher: Cell Press

URL: http://dx.doi.org/10.1016/j.cmet.2015.07.021

DOI: 10.1016/j.cmet.2015.07.021


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