Lookup NU author(s): Professor Fiona Matthews,
Dr Blossom Stephan
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
BackgroundChanges in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).MethodsUniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.ResultsThe published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P <= .01).ConclusionApplying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.
Author(s): Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, Brayne C, Matthews FE, Stephan BCM, Lipton RB, Katz MJ, Ritchie K, Carriere I, Ancelin ML, Lam LCW, Wong CHY, Fung AWT, Guaita A, Vaccaro R, Davin A, Ganguli M, Dodge H, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabarbara J, Cohort Studies Memory Internationa
Publication type: Article
Publication status: Published
Journal: PLoS One
Online publication date: 05/11/2015
Acceptance date: 21/10/2015
Date deposited: 20/04/2016
ISSN (electronic): 1932-6203
Publisher: Public Library of Science
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