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Lookup NU author(s): Dr Vinod Hegade,
Dr Stuart Kendrick,
Professor David Jones
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Pruritus (itch) is a common complication of cholestatic liver diseases (CLD). It can be a distressing and debilitating symptom, causing significant impairment in quality of life. Treatment of pruritus in liver diseases can be challenging and requires specific management with early initiation and a step-wise approach using specific drugs. Clinical trials are ongoing with novel agents that demonstrate potential efficacy. Patients with cholestatic pruritus are likely to present to a variety of clinicians who would benefit from medical awareness of available treatment options. In this review, we outline the pharmaceutical agents currently used to treat cholestatic pruritus and provide the evidence base for targeted symptom control of itch in liver diseases. We also highlight recent developments in the pathophysiology of cholestatic pruritus and the emerging novel therapies.
Author(s): Hegade VS, Kendrick SFW, Jones DEJ
Publication type: Article
Publication status: Published
Journal: Clinical Medicine
Print publication date: 01/08/2015
Acceptance date: 01/01/1900
ISSN (print): 1470-2118
ISSN (electronic): 1473-4893
Publisher: Royal College of Physicians
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