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Mortality rates in community-dwelling Tanzanians with dementia and mild cognitive impairment: a 4-year follow-up study

Lookup NU author(s): Dr Stella-Maria Paddick, Dr Catherine Dotchin, Professor Richard Walker

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Abstract

Methods: during Phase I of the prevalence study, 1,198 people aged 70 years and over were screened, and a stratified sample of 296 was assessed for the presence of dementia or MCI in Phase II. Seventy-eight people had dementia and 46 had MCI. Four years after diagnosis, we attempted to follow-up all those seen in Phase II and record all deaths.Results: of the 296, follow-up data were available for 287 (97.0%), including 77 with dementia and 45 with MCI. Of the 172 with no cognitive impairment, 165 (95.9%) were followed up and a sample of 89 people selected as representative of the background population. Forty-eight people with dementia (62.3%), 19 with MCI (42.2%) and 11 with no cognitive impairment (12.4%) had died at 4-year follow-up. After adjusting for the effects of age, gender and education, the hazard ratio was 6.33 (95% CI 3.19-12.58) for dementia and 3.57 (95% CI 1.64-7.79) for MCI relative to people with no cognitive impairment. Mortality rates were highest in those with vascular dementia.Conclusion: dementia and MCI were associated with excess mortality relative to those with no cognitive impairment.


Publication metadata

Author(s): Paddick SM, Kisoli A, Dotchin CL, Gray WK, Chaote P, Longdon A, Walker RW

Publication type: Article

Publication status: Published

Journal: Age and Ageing

Year: 2015

Volume: 44

Issue: 4

Pages: 636-641

Print publication date: 01/07/2015

Online publication date: 26/04/2015

Acceptance date: 31/12/2014

ISSN (print): 0002-0729

ISSN (electronic): 1468-2834

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/ageing/afv048

DOI: 10.1093/ageing/afv048


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