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CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia

Lookup NU author(s): Judith Weiland, Dr Alex Elder, Dr Victoria Forster, Professor Olaf Heidenreich, Professor Josef Vormoor

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Abstract

Over the last 20-30 years CD19 has gained attention as a potential target in the therapy of B-cell malignancies. In particular, targeting CD19 with the bispecific T-cell engager (BiTE) antibody Blinatumomab and T-cells modified by chimeric antigen receptors (CAR) has shown promising efficacy in early phase clinical trials for adults and children with precursor B-cell ALL (BCP-ALL). This review will discuss the rationale behind targeting CD19 in BCP-ALL and its potential importance in BCP-ALL signaling pathways. Pediatr Blood Cancer 2015;62:1144-1148. (c) 2015 Wiley Periodicals, Inc.


Publication metadata

Author(s): Weiland J, Elder A, Forster V, Heidenreich O, Koschmieder S, Vormoor J

Publication type: Review

Publication status: Published

Journal: Pediatric Blood & Cancer

Year: 2015

Volume: 62

Issue: 7

Pages: 1144-1148

Print publication date: 01/07/2015

Online publication date: 08/03/2015

Acceptance date: 16/01/2015

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: WILEY-BLACKWELL

URL: http://dx.doi.org/10.1002/pbc.25462

DOI: 10.1002/pbc.25462


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