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The first international workshop on the epigenetics of osteoarthritis

Lookup NU author(s): Dr Louise Reynard, Andrew Skelton, David Young, Professor John Loughlin

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of disease-modifying drugs resulting, to a significant degree, from our incomplete understanding of the underlying molecular mechanisms of the disease. Emerging evidence points to a role of epigenetics in the pathogenesis of OA, but research in this area is still in its early stages. In order to summarize current knowledge and to facilitate the potential coordination of future research activities, the first international workshop on the epigenetics of OA was held in Amsterdam in October 2015. Recent findings on DNA methylation and hydroxymethylation, histone modifications, non-coding RNAs and other epigenetic mechanisms were presented and discussed. The workshop demonstrated the advantage of bringing together those working in this nascent field and highlights from the event are summarized in this report in the form of summaries from invited speakers and organizers.


Publication metadata

Author(s): Meulenbelt IM, Bhutani N, den Hollander W, Gay S, Oppermann U, Reynard LN, Skelton AJ, Young DA, Beier F, Loughlin J

Publication type: Article

Publication status: Published

Journal: Connective Tissue Research

Year: 2017

Volume: 58

Issue: 1

Pages: 37-48

Online publication date: 30/03/2016

Acceptance date: 10/03/2016

Date deposited: 03/05/2016

ISSN (print): 0300-8207

ISSN (electronic): 1607-8438

Publisher: Taylor & Francis

URL: http://dx.doi.org/10.3109/03008207.2016.1168409

DOI: 10.3109/03008207.2016.1168409

PubMed id: 27028588


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