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Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study

Lookup NU author(s): Dr Katherine Livingstone, Dr Carlos Celis Morales, Professor Lorraine Brennan, Professor John Mathers

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Abstract

The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AAv. TT: +14 cm; P=0003) and BMI (+09 kg/m(2); P=0001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 14 kg/m(2) greater BMI (P-trend=0028) and 31 cm greater WC (P-trend=0045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.

Publication metadata

Author(s): Livingstone KM, Celis-Morales C, Navas-Carretero S, San-Cristobal R, Forster H, O'Donovan CB, Woolhead C, Marsaux CFM, Macready AL, Fallaize R, Kolossa S, Tsirigoti L, Lambrinou CP, Moschonis G, Godlewska M, Surwillo A, Drevon CA, Manios Y, Traczyk I, Gibney ER, Brennan L, Walsh MC, Lovegrove JA, Martinez JA, Saris WHM, Daniel H, Gibney M, Mathers JC, Food4Me Study

Publication type: Article

Publication status: Published

Journal: British Journal of Nutrition

Year: 2016

Volume: 115

Issue: 3

Pages: 440-448

Print publication date: 01/02/2016

Online publication date: 01/12/2015

Acceptance date: 28/10/2015

ISSN (print): 0007-1145

ISSN (electronic): 1475-2662

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S0007114515004675

DOI: 10.1017/S0007114515004675

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